Brian L West Selected Research

Macrophage Colony-Stimulating Factor

1/2022	Results from Phase I Extension Study Assessing Pexidartinib Treatment in Six Cohorts with Solid Tumors including TGCT, and Abnormal CSF1 Transcripts in TGCT.
11/2019	Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments.
1/2019	Inhibition of TAMs improves the response to docetaxel in castration-resistant prostate cancer.
4/2016	Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study.
1/2016	Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization.
1/2016	Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits.
11/2015	Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice.
7/2015	Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.
5/2015	Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.
3/2015	CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy.

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Brian L West Research Topics

Disease

24	Neoplasms (Cancer) 01/2022 - 03/2006
6	Melanoma (Melanoma, Malignant) 01/2018 - 02/2008
4	Neuroinflammatory Diseases 10/2020 - 04/2016
3	Cognitive Dysfunction 05/2020 - 12/2016
3	Inflammation (Inflammations) 11/2019 - 07/2004
3	Prostatic Neoplasms (Prostate Cancer) 01/2019 - 03/2015
3	Glioblastoma (Glioblastoma Multiforme) 04/2016 - 05/2012
2	Demyelinating Diseases (Demyelinating Disease) 01/2021 - 01/2019
2	Brain Injuries (Brain Injury) 05/2020 - 01/2016
2	Breast Neoplasms (Breast Cancer) 11/2019 - 06/2011
2	Alzheimer Disease (Alzheimer's Disease) 04/2016 - 08/2015
2	Neoplasm Metastasis (Metastasis) 09/2015 - 06/2011
2	Adenocarcinoma 09/2014 - 06/2011
1	Hypercapnia 01/2022
1	Gliosis 01/2021
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020
1	Chemotherapy-Related Cognitive Impairment 11/2019
1	Weight Gain 01/2018
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2018
1	Mental Disorders (Mental Disorder) 01/2018
1	Brain Neoplasms (Brain Tumor) 12/2016
1	Memory Disorders (Memory Loss) 01/2016
1	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 11/2015
1	Disease Progression 09/2015
1	Carcinoma (Carcinomatosis) 09/2015
1	Bone Neoplasms (Bone Cancer) 09/2015
1	Cancer Pain 09/2015
1	Pain (Aches) 09/2015
1	Giant Cell Tumor of Tendon Sheath 07/2015
1	Giant Cell Tumors (Giant Cell Tumor) 07/2015
1	Pancreatic Neoplasms (Pancreatic Cancer) 09/2014
1	Sarcoma (Soft Tissue Sarcoma) 04/2013
1	Tics (Tic) 02/2013
1	Neurofibroma 01/2013
1	Papillary Thyroid Cancer 12/2011
1	Obesity 01/2009
1	Body Weight (Weight, Body) 01/2009

Drug/Important Bio-Agent (IBA)

16	pexidartinibIBA 01/2022 - 05/2012
13	Macrophage Colony-Stimulating FactorIBA 01/2022 - 05/2012
6	Phosphotransferases (Kinase)IBA 01/2020 - 03/2006
4	CytokinesIBA 11/2019 - 01/2014
4	PLX5622IBA 11/2019 - 08/2015
3	Tyrosine Kinase InhibitorsIBA 01/2022 - 06/2015
3	Pharmaceutical PreparationsIBA 04/2016 - 04/2013
2	CalciumIBA 01/2022 - 01/2016
2	fms-Like Tyrosine Kinase 3IBA 01/2022 - 01/2020
2	RNA (Ribonucleic Acid)IBA 11/2019 - 05/2012
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2019 - 06/2011
2	AndrogensIBA 01/2019 - 03/2015
2	LigandsIBA 04/2016 - 01/2016
2	Macrophage Colony-Stimulating Factor Receptor (Receptor, Macrophage Colony Stimulating Factor)IBA 05/2015 - 01/2014
2	Protein Kinases (Protein Kinase)IBA 09/2010 - 02/2008
1	Adenosine (Adenocard)FDA LinkGeneric 01/2022
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2022
1	CuprizoneIBA 01/2021
1	palmitoyl-protein thioesteraseIBA 10/2020
1	HeliumIBA 05/2020
1	IonsIBA 05/2020
1	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2019
1	Colony-Stimulating Factors (Colony Stimulating Factor)IBA 01/2019
1	Interleukin-10 (Interleukin 10)IBA 01/2019
1	Retinaldehyde (Retinal)IBA 01/2019
1	Docetaxel (Taxotere)FDA Link 01/2019
1	CytosineIBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	Stem Cell FactorIBA 04/2016
1	Amyloid (Amyloid Fibrils)IBA 04/2016
1	Mitogen-Activated Protein KinasesIBA 10/2015
1	VaccinesIBA 09/2015
1	Formaldehyde (Formol)FDA Link 09/2015
1	ChemokinesIBA 09/2015
1	Peptides (Polypeptides)IBA 09/2015
1	Analgesics (Analgesic Drugs)IBA 09/2015
1	Protein Subunit VaccinesIBA 09/2015
1	quizartinibIBA 06/2015
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 06/2015
1	VemurafenibIBA 05/2015
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 09/2014
1	Cell Surface ReceptorsIBA 04/2013
1	CC ChemokinesIBA 02/2013
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 02/2013
1	ErbB Receptors (EGF Receptor)IBA 05/2012
1	Epidermal Growth Factor (EGF)IBA 05/2012
1	Doxycycline (Periostat)FDA LinkGeneric 12/2011
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2011
1	Oncogene Proteins (Oncogene Protein)IBA 12/2011
1	Proto-Oncogene Proteins B-rafIBA 09/2010
1	Glucose (Dextrose)FDA LinkGeneric 01/2009
1	CholesterolIBA 01/2009
1	Triglycerides (Triacylglycerol)IBA 01/2009
1	AdiponectinIBA 01/2009
1	PLX 4720IBA 02/2008

Therapy/Procedure

10	Therapeutics 01/2019 - 06/2011
3	Drug Therapy (Chemotherapy) 11/2019 - 06/2011
3	Immunotherapy 09/2015 - 01/2014
1	Duration of Therapy 01/2022
1	Aftercare (After-Treatment) 01/2019
1	Castration 01/2019
1	Cranial Irradiation 12/2016
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2014